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Abstract
Cardiovascular diseases are the leading cause of disability and mortality in Russia, which determines the topicality of investigations devoted to risk factors of their development and progression. Considering the complex physiological regulatory mechanisms of the circulatory system, that cause circadian changes of its functioning, light-induced desynchronosis may act as one of the risk factors for cardiovascular disease. The aim of this study was to investigate the effect of light desynchronosis on the microcirculation in white rats. Materials and methods. The study was carried out on 20 white male rats, which were divided into two groups: experimental - 10 rats exposed to the change light-mode and control - animals in natural light-mode. Microcirculation was measured by laser Doppler flowmetry. Main results. At the stage of temporary mismatch (the first day of the experiment) microcirculation disorders were mild and manifested by a moderate increase in myogenic tone, which did not lead to significant perfusion shifts. The decrease of skin perfusion was found at the stage of regulatory violations of light-induced desynchronosis, that was accompanied by changes of both passive and active flow modulation mechanisms intensity. Skin perfusion decrease was maintained up to 21st day of the experiment and at the stage of structural defects was accompanied by a marked inhibition of the total blood flow modulation due to reduction of endothelial, myogenic, cardiac and respiratory oscillations. Conclusions. Light-induced desynchronosis causes the microcirculatory disturbances occurrence and gradually development in association with violation of neurogenic and myogenic microvascular tone, as well as endothelial dysfunction. The progression of these disorders reflects its negative influence on the circulatory system regulatory mechanisms that suggests consideration of light-induced desynchronosis as a risk factor for cardiovascular disease.
Highlights
Cardiovascular diseases are the leading cause of disability and mortality in Russia, which determines the topicality of investigations devoted to risk factors of their development and progression
Microcirculation was measured by laser Doppler flowmetry
The decrease of skin perfusion was found at the stage of regulatory violations of light-induced desynchronosis, that was accompanied by changes of both passive and active flow modulation mechanisms intensity
Summary
Учитывая наличие сложных физиологических регуляторных механизмов системы кровообращения, обеспечивающих циркадные изменения ее функционирования, одним из факторов риска кардиоваскулярной патологии может являться световой десинхроноз. В стадию структурных нарушений на 21–е сутки эксперимента сохраняется снижение перфузии, сопровождающееся выраженным угнетением общей модуляции кровотока за счет снижения абсолютных амплитуд эндотелиальных, миогенных, кардиальных и дыхательных колебаний. Прогрессирование указанных нарушений отражает негативное влияние на регуляторные механизмы системы кровообращение в соответствии с течением стадий светового десинхроноза, что позволяет рассматривать его в качестве фактора риска кардиоваскулярной патологии. Результаты исследования В результате проведенного исследования установлено, что у животных опытной группы на 1–е сутки эксперимента имеется тенденция к снижению перфузии относительно контрольных значений. При этом нормированные амплитуды колебаний, характеризующих активные механизмы модуляции кровотока, находятся в пределах вариабельности контрольных значений Показатели абсолютных амплитуд колебаний, характеризующих пассивные механизмы модуляции кровотока, снижены относительно контрольных значений: дыхательных – на 43 %, пульсовых – на 25 % (табл.). При этом статистических значимых изменений среднеквадратического отклонения и коэффициента вариации не выявлено (табл. 1)
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