Abstract
Svanes, K. Microcirculatory changes and general responses to 5-Hydroxytryptamine in Normothermic and hypothermic mice. Acta physiol. scand. 1968. 72. 404–411. 5-hydroxytryptamine (5-HT) was injected i.v. into unanesthetized, anesthetized normothermic and hypothermic (21–22° C) mice, and the general effects of the injections were observed. In addition, conjunctival microscopy and hematocrit determinations were performed. 5-HT was found to cause a syndrome characterized by exophtalmus, respiratory distress, cyanosis, edema, evacuation of bowels, salivation, lethargy, constriction and slow blood flow in the metarterioles, dilatation and stasis in the venules, and hemoconcentration. In general the reaction to 5-HT was relatively mild in unanesthetized mice, moderate in anesthetized normothermic mice and severe in hypothermic mice. The marked reaction to 5-HT under hypothermia might be due to retarded elimination of 5-HT from the blood.
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