Microcirculation of the lungs in acute pulmonary edema

Abstract

Introduction. The relevance of the work is determined by the high mortality in acute pulmonary edema (APE), the speed of development of the process, the lack of effective methods of treatment and comprehensive studies of acute pulmonary edema used in vivo methods of research.The aim of this work was to study the pathogenesis of APE in the experiment using biomicroscopy.Material and methods. The microcirculation of lungs was studied in the dynamics of APE by direct and indirect methods: biomicroscopy of lungs using the chamber of the rat, laser Doppler flowmetry of the lungs, morphological and histological examination of lungs.Results. The decisive role of lymphatic microvessels in the pathogenesis of APE was shown. All studied indicators complemented each other and were the result of impaired microcirculation in the blood and lymph microvasculature of the lungs. In the surviving animals with APE, there was an initial recovery of lymph flow in the lungs. Restoration of venular tone, reduction of edema in the interstitium of the lungs and morphological manifestations occurred after restoration of lymphocirculation, which is in favor of the decisive role of the lymphatic system in the pathogenesis of APE. It is necessary to create pharmacological agents with lymph­stimulating activity.