Microchimerism in the transfused obstetric population.

Abstract

Microchimerism (MC), the coexistence of allogeneic populations of cells within a host, is well described in pregnancy and blood transfusion. To date, transfusion-associated MC (TA-MC) appears unique to patients transfused after severe traumatic injury. We sought to determine whether transfusion in the peripartum period results in enduring, high-level TA-MC. We conducted a prospective cohort study of 22 women who were newly transfused within 48h of delivery. Two subjects showed evidence of transient TA-MC; however, MC was not detected at 6weeks and 6months. The negative findings suggest that enduring TA-MC does not occur in this population.