Microchimerism in children with perinatal pathology

Abstract

The article presents the opportunity to identify the phenomenon of microchimerism in the genes of HLA loci A, B, C, DRB1, DQB1 by PCR-SSP. The sample group consists of the mothers and newborns with intrauterine growth retardation (IUGR) (20 pairs), hemolytic disease of the newborn (HDN) (21 pairs), after external rotation of the fetus (11 pairs), from women with malignancy (1 pair), autoimmune thrombocytopenia (1 pair), tuberous sclerosis (1 pair), bradyarrhythmias (1 pair). The control group consists of 13 pairs. Of the 138 studied blood samples microchimerism was detected in 33.9 % of patients and in 19.2 % of control group. Maternal microchimerism was found only in patients with perinatal pathology and was not met in the control group. Fetal microchimerism was distributed in all studied groups, but among patients with perinatal pathology, it was met three times more frequent than in the control group (23.9 % and 7.7 %, respectively). Significantly more frequent microchimerism was found in the group of patients with HDN than in the control (p = 0.04). In the other groups the occurrence of the chimeric gene from the control group was not statistically significant