Abstract
In this paper, an Ag nanoparticles (AgNPs) modified multimode fiber (MMF) SERS probe prepared based on sol self-assembly method is proposed and fabricated. Different fiber SERS probes (AgNPs-MMF-x, x is the self-assembly time) are obtained by adjusting the self-assembly time. Using rhodamine 6G (R6G) solution as the probe molecule, the far-end performances of the prepared fiber SERS probe are studied, and the AgNPs-MMF-30 probe with obvious advantages in SERS performance is obtained. The limit of detection (LOD) for R6G is as low as 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-9</sup> M, demonstrating the high sensitivity of AgNPs-MMF-30 probe. The enhancement factor (EF) of AgNPs-MMF-30 probe to 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-7</sup> M R6G is about 1.36 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">8</sup> . In addition, the AgNPs-MMF-30 probe has an outstanding reproducibility across the entire area with the maximum value of relative standard deviation (RSD) of less than 10.94%. The AgNPs-MMF-30 probe exhibit a long-term stability regarding Raman enhancement of up to 35 days. Importantly, the high-performance AgNPs-MMF-30 probe is further applied as a highly sensitive SERS platform for the trace detection of antibiotic in milk. The fiber SERS probe has the characteristics of fast, effective, remote real-time detection and so on, so it has great potential application in biochemical sensing and food security.
Highlights
In recent years, the unreasonable use of antibiotics in animal breeding industry and the content of pollutants in dairy products have aroused people’s great attention
The silver sol and rhodamine 6G (R6G) with a concentration of 10−3 M are mixed in equal volume, and the Raman intensity of the mixed solution is measured with bare fibers etched for different time to determine the length of microcavity when the enhancement effect is strongest
The results indicate that the Ag nanoparticles (AgNPs)-multimode fiber (MMF)-30 probe has high sensitivity, and the limit of detection (LOD) for adsorbed R6G molecules is 10−9 M under this experimental condition
Summary
The unreasonable use of antibiotics in animal breeding industry and the content of pollutants in dairy products have aroused people’s great attention. The most commonly used detection techniques for enrofloxacin and amoxicillin antibiotics include high-performance liquid chromatography (HPLC) [6], [7], molecularly imprinted polymer method [8], [9], chromatography [10] and liquid mass spectrometry [11], [12] These methods have high accuracy and reliability, they all require complicated pre-processing steps and expensive experimental equipment, long test time, specialized operations and so on. Surface enhanced Raman scattering (SERS) spectroscopy has the spectral characteristic of “fingerprint” [14] It can reflect the molecular structure information, which is an effective method to detect antibiotics. It provides an effective new way for on-site detection of antibiotic residues in milk
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