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Abstract
The effects of various concentrations of toad bufanolide diene(BD) on the growth of Tetrahymena thermophila BF5 were investigated by means of a thermal activity monitor(TAM) system.The extent and duration of toxic effects on metabolism were evaluated by studying the growth rate constant(k),maximum heat-output power(Pmax) and half inhibitory concentration(IC50).Experimental results showed that the values of k and Pmax decreased as the concentrations of BD increased.Furthermore,the growth rate constant(k) was linked to the concentration of BD:rcinobufagin= 0.9910(IC50=119.2 μg·mL-1);rbufalin=0.9923(IC50=106.14 μg·mL-1);rbufotalin=0.9977(IC50=73.80 μg·mL-1);rgamabufotalin=0.9923(IC50=54.75 μg·mL-1).The sequence of toxicity for the four BDs was:gamabufotalinbufotalinbufalincinobufagin.The α-hydroxy group at C11,β-hydroxy group at C14,β-acetoxy at C16 and the non-dehydrolysis between C14 and C15 can possibly improve the toxicity of BD towards Tetrahymena thermophila BF5.
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