Abstract
The use of contrast agents is becoming a routine practice in diagnostic ultrasound imaging. Microbubble contrast agents are proving to be a safe and practical way of enhancing conventional ultrasound images. This paper discusses the concept of using microbubble contrast agents in the vibro-acoustography (VA) technique. A brief background of microbubbles and their clinical applications is given as well as a summary of the different attempts at modeling microbubble contrast agents in ultrasound fields. A general Keller–Herring equation is modified to mathematically model the interaction of encapsulated microbubbles in blood with VA ultrasound. The frequency response and scattered pressure of microbubbles with initial radius of 1 and 3 m are presented. This method is accurate for pressure amplitudes up to 500 kPa. Understanding this interaction is important for the correct interpretation of clinical investigations when using VA.
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