Year-end Sale % OFF 
Abstract
BackgroundThe increasing incidence of cancer and intestinal mucositis induced by chemotherapeutics are causing worldwide concern. Many approaches such as fecal microbiota transplantation (FMT) have been used to minimize mucositis. However, it is still unknown whether FMT from a donor with beneficial gut microbiota results in more effective intestinal function in the recipient. Recently, we found that alginate oligosaccharides (AOS) benefit murine gut microbiota through increasing “beneficial” microbes to rescue busulfan induced mucositis.ResultsIn the current investigation, FMT from AOS-dosed mice improved small intestine function over FMT from control mice through the recovery of gene expression and an increase in the levels of cell junction proteins. FMT from AOS-dosed mice showed superior benefits over FMT from control mice on recipient gut microbiotas through an increase in “beneficial” microbes such as Leuconostocaceae and recovery in blood metabolome. Furthermore, the correlation of gut microbiota and blood metabolites suggested that the “beneficial” microbe Lactobacillales helped with the recovery of blood metabolites, while the “harmful” microbe Mycoplasmatales did not.ConclusionThe data confirm our hypothesis that FMT from a donor with superior microbes leads to a more profound recovery of small intestinal function. We propose that gut microbiota from naturally produced AOS-treated donor may be used to prevent small intestinal mucositis induced by chemotherapeutics or other factors in recipients.3fRPjgD1tu64W3SMZQXKgEVideo
Highlights
The annual incidence of cancer is continuing to increase and cause worldwide concern and frustration [1,2,3,4]
alginate oligosaccharides (AOS) benefited gut microbiota In a recent report, we revealed that AOS mitigated small intestine cell membranes damage especially cell junctions and microvilli by the anticancer drug busulfan; simultaneously, AOS supported the blood metabolome to assist small intestinal recovery [23]
In the current investigation, we explored changes in gut microbiota after 2 weeks of busulfan and/or AOS treatment [there were three treatment groups: (1) A0: vehicle control; (2) BA0 [injected with 40 mg/kg body weight (BW) busulfan once dosed with ddH2O]; (3) BA10
Summary
The annual incidence of cancer is continuing to increase and cause worldwide concern and frustration [1,2,3,4]. Alginate oligosaccharides (AOS) are natural products derived from the degradation of alginate that have attractive pharmaceutical properties [16,17,18] They have been found to be anti-inflammatory [17], anti-apoptotic [19], antiproliferation [20], and to have antioxidant [16, 19, 21] and even anti-cancer activities [22]. The increasing incidence of cancer and intestinal mucositis induced by chemotherapeutics are causing worldwide concern. Many approaches such as fecal microbiota transplantation (FMT) have been used to minimize mucositis. We found that alginate oligosaccharides (AOS) benefit murine gut microbiota through increasing “beneficial” microbes to rescue busulfan induced mucositis
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
