Microbiome-microbolome and Disease: A Covert Nexus

Abstract

The microbial diversity associated with all life forms, including humans, plants, and animals, is magnificent. Different regions of the body are inhabited by different species and forms of microbes. Such transient interaction with the microbiome affects all organisms concerning their physiological functioning as well as disease. Inherent functions of the body, like immune reactions, developmental pathways, metabolic and endocrinological attributes coupled with genetics, lifestyle factors, diet, and introduction of antibiotics in the system, and other metabolites, all play an important integrative role in the maintenance or loss of health. Research indicates that the occurrence of diverse types of health conditions, like autoimmune disorders, neurological problems like Alzheimer’s, mood alterations, cancer, and even social behavior, are related to the changes in the microbial population in the human gastrointestinal tract. This paper highlights the different effects of the gut microbiome-metabolome conjugate and its effect on health conditions, with a brief reflection on the diverse modes of advanced treatment and future research using nanotechnology and artificial intelligence.