Abstract
One of the main directions of improving the concept of treatment of diseases of the gastrointestinal tract and liver, which is accompanied by dysfunction of the hepatobiliary system and intestines, was the search and development of herbal remedies with hepatoprotective effect with a laxative effect and concomitant prebiotic activity. Aim of the research: to study the antimicrobial and prebiotic properties of the studied phytosubstance obtained from the fruits of Prunus domestica. Materials and methods. The study of the antimicrobial activity of the test sample of plum fruit extract with fibers was performed in vitro by the method of multiple serial dilutions. The reference strains of the following microorganisms were used as the microbiological model: S.aureus-ATCC-25923, E.сoli-ATCC-25922, P. aéruginosa-ATCC-27853, B. subtilis-ATCC-6633, C.albicans-ATCC-885653. The determination of the prebiotic properties of the studied sample was carried out by the method of cultivation of bacteria Bifidobacterium bifidum No. 1 and L. rhamnosus R0011 ND on nutrient media, which included the composition of plum fruit with fibers. Results. Studies on the antimicrobial activity of plum fruit extract with fibers showed that the studied phytosubstance does not reveal antagonistic properties both with respect to gram-positive and gram-negative bacteria, as well as in the case of Candida fungi. The results of studies on the study of the prebiotic properties of the studied extract confirmed the improvement of the main physiological parameters of the culture of bifidobacteria strain Bifidobacterium bifidum No. 1 and the strain lactobacillus L. rhamnosus R0011 ND when the fruit plums with fibers were added to the culture medium. Conclusions. The conducted studies allowed to establish the prebiotic properties of the studied extract of plum fruits with fibers, which proves the promise of its use in complex therapy schemes for gastrointestinal pathology.
Highlights
The concept of hepatoprotective agents’ use is to minimize the effects of toxic agents on the liver
Results of research The first stage of research was the determination of the antimicrobial activity of the studied extract of plum fruits with fibers
The extract of fruit plum with fibers were tested against Pharmacopoeia strains of gram negative (E. coli ATCC 25922, Р. aеruginosa-ATCC-27853) and gram positive (S. aureus ATCC 25923, B. subtilis-ATCC-6633) bacteria, as well as against the fungal strain of Candida albicans (ATCC 885653)
Summary
The concept of hepatoprotective agents’ use is to minimize the effects of toxic agents on the liver. Most medicinal products and xenobiotics are converted into the liver and initiate the first phase of the enzyme detoxification reaction, which causes the formation of active metabolites (products of lipid peroxidation) and leads to membrane-disruptive effect. The key role of the destabilizing action of free radicals, products of lipid peroxidation in the pathogenesis of liver diseases was proved, and the possibility of their treatment with hepatoprotective drugs was substantiated. The promising direction of the pharmacotherapy of liver disease is the use of phytopreparations. The advantages of pharmacotherapy with herbal medicines are: the absence of toxic effects, the possibility of prolonged use, a significant range and “softness” of the effect, the optimal pharmacoeconomic component, the possibility to use in patient at all age groups [1, 2]. The Prunus Domestica attracted the interesting and unique chemical content of its fruits and its wide application in folk medicine was chosen as object for experimental research [3]
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