Abstract
Nitrile-hydrolysing enzymes such as nitrile hydratase, nitrilase and amidase have great potential as catalysts in processing organic chemicals because they can convert nitriles to the corresponding higher-value amides or acids. Very recently, the use of bacterial nitrile hydratase for industrial production of the important chemical commodity, acrylamide, was pioneered in Japan. We review here both the enzymatic production of acrylamide, and other recent progress in microbial transformation of nitriles.
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