Abstract
Microbial transformation of diosgenin ( 1) by Syncephalastrum racemosum yielded five new polar metabolites, which were identified as (25 R)-spirost-5-en-3β,7α,9α-triol-12-one ( 2), (25 R)-spirost-5-en-3β,9α,12α-triol-7-one ( 3), (25 R)-spirost-5-en-3β,9α-diol-7,12-dione( 4), (25 R)-spirost-4-en-9α,12β,14α-triol-3-one( 5), and (25 S)-spirost-4-en-9α,14α,25β-triol-3-one ( 6). Compounds 1– 6 exhibited moderate cytotoxicity against K562 cells and among them compounds 2, 3, and 6 were more potent than the parent compound 1.
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