Abstract
The current study was aimed to determine the pattern of antimicrobial resistivity of common microorganisms isolated from the most common grades of diabetic foot ulcers (DFUs) presenting at Mayo Hospital, Lahore, Pakistan. A total of 293 patients were included in the study conducted from January 2019 to December 2020. Deep-seated tissue samples of dimensions 0.5×0.5 cm were taken from the ulcer after surgical debridement, washed with saline, and immediately sent to the laboratory for culture and sensitivity (C&S). Data were analyzed by using SPSS 26. Grade 2 and Grade 3 DFUs (26.62% and 49.14%, respectively) were the most abundant of all DFUs, while Staphylococcus aureus was the most abundant bacteria. The polymicrobial growth pattern was found to be dominant in the current study. The incidence of MRSA was 68.4%(26/38) and 66.2%(49/74) in grades 2 and 3, respectively. The overall incidence of gram-negative microbes increased with an increase in the grade of ulcer. Hence, it can be concluded that early identification and grading of the disease can assist in the early initiation of empirical treatment and may reduce the unwanted morbidity of the disease. Furthermore, ultimate treatment should always be based on culture and sensitivity reported to minimize the disease's socioeconomic burden and morbidity.
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