Abstract
AbstractMicrobial metabolism of the diterpene sclareol (1) was studied. Screening studies have shown a number of microorganisms capable of metabolizing 1. Preparative‐scale fermentation with Septomyxa affinis ATCC 6737 has resulted in the production of three fungal metabolites that have been characterized by 2D‐NMR techniques and chemical reactions. These metabolites have been identified as 8α,13β‐dihydroxylabd‐14‐en‐3‐one (2), labd‐14‐ene‐3β.8α,13β‐triol (4), and labd‐14‐ene‐2α,8α,13β‐triol (6).
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