Abstract
Background: Rheumatoid arthritis (RA) is chronic systemic inflammatory immune disease, occur when the function of the immune system become incorrectly. The main cause of RA unclear, but there are suggestion about development of RA, of which role the genetic and environmental factors, additionally role of microbial infections. Objectives: This study aimed to illustrate the relationship the rheumatoid arthritis (RA) and microbial infections. Methods: This work has utilized on clinically assured 40 RA subjects with different age, their age ranged from 25 to 75 years old attended to rheumatology clinic of the Medical Marjan City, Imam Ali hospital, and Imam Sadiq hospital during the period from August 2019 to December 2019.Urine and blood samples were used for bacterial isolation. Mycoplasma and Epstein-Barr virus were detected by enzyme linked immunosorbent assay (ELISA). Results: Seven (17.5%) bacterial isolates was obtained from urine patients. Bacterial cultures revealed no growth for patients' blood samples,moreover no bacterial growth for all control samples. Most bacterial isolates was Proteus mirabilis. Highest significant result (P value < 0.001) for anti-Mycoplasma pneumoniaIgG andanti-EBV IgG in RA patients than control. Conclusion: Proteus mirabilis,Mycoplasma, and Epstein-Barr virusare associated with RA.
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