Abstract

Biotransformation of sclareol with different microorganisms led to 2α-, 3β- and 18-hydroxy-sclareol. Cunninghamella elegans additionally formed the hitherto unknown 19-hydroxy-sclareol. The phylogenetic position of a strain is mirrored in its ability to form these metabolises. The ability of fungi to convert this substrate is higher than that of the bacteria. Thus 2α-hydroxy-sclareol is only formed by zygomycotina and some deuteromycotina. The most active strains belong to the zygomycotina and basidiomycotina. Within the bacteria, Gram-positive bacteria are more active than Gram-negative ones.

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