Abstract
The hydroxylation of 2-phenylpropionic acid (PPH) to 2-(p-hydroxyphenyl)propionic acid (HPPH) was investigated using various microorganisms. The highest hydroxylating activity was found in Streptomyces rimosus ATCC 10907. The reaction product was isolated and identified as 2-(p-Miydroxyphenyl)propionic acid, which had no specific rotation, indicating that the reaction was not stereoselective at the benzylic position. In a 5-1 jar fermentor containing a medium consisting of 2% sorbitol, 2% soybean meal, and 1% malt extract (pH 7.2), the conversion rate from 0.2% of PPH reached 60% using a PPH-resistant mutant, KY-661-18.
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