Abstract
The brefeldin A (BFA) derivatives 4- O-acetyl BFA, 7- O-acetyl BFA, and 4- O- d-glucosyl BFA were found by the microbial conversion of BFA. 4- O- d-Glucosyl BFA is a novel compound produced by the conversion of BFA with Streptomyces sp. Q53834. The cytotoxicity and antifungal activity of all of the compounds were markedly less than those of BFA.
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