Abstract
Claire Fraser and co-workers at The Institute for Genomic Research (TIGR) have recently reported the complete genome sequences of two more chlamydial strains – a mouse pneumonitis (MoPn) strain of Chlamydia trachomatis (1 Mb) and Chlamydia pneumoniae strain AR39 (1.2 Mb) – in addition to the two already completed. The MoPn genome is broadly similar to that of the previously sequenced C. trachomatis serovar D, with some differences in an ∼50-kb ‘plasticity zone’, where MoPn contains three copies of a gene for a >3000 amino-acid putative toxin. The C. pneumoniae AR39 chromosome is >99.9% identical to the previously sequenced C. pneumoniae CWL029 genome, but contains a novel 4.5-kb circular single-stranded DNA bacteriophage, the first C. pneumoniae phage to be reported. Both genomes can be searched via the TIGR web site (http://www.tigr.org)
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