Microbial Diseases of Laboratory Animals and its monitoring Tools

Abstract

Microbial diseases pose significant challenges in experimental research, impacting both animal welfare and research outcomes. The review covers a wide range of microbial pathogens, including bacteria, viruses, fungi, and parasites, that commonly affect laboratory animals. It explores the etiology, pathogenesis, and clinical manifestations associated with these pathogens, highlighting their influence on experimental results. Extensively discussed about the monitoring assays employed for microbial disease detection in experimental animals. Traditional and modern techniques are considered, including microbiological culturing, serological assays, molecular diagnostics, histopathology, and advanced imaging methods. Regular health monitoring programs for laboratory animals, emphasizing the significance of early detection and intervention to prevent disease outbreaks and maintain animal welfare. Emerging trends and technologies in microbial disease monitoring, such as next-generation sequencing, metagenomics, and high-throughput screening, are also explored. This review aims to provide researchers, laboratory animal professionals, and regulatory authorities with a comprehensive resource for understanding microbial diseases in experimental animals and selecting appropriate monitoring assay. For the Scientists and Veterinarians this overall review gives a glimpse for implementing effective monitoring strategies, identifying and managing microbial diseases, ensuring the well-being of laboratory animals. The synthesis of current knowledge and best practices will enhance the scientific rigor and reproducibility of experimental studies involving animals. In conclusion, this review emphasizes the critical importance of microbial disease monitoring in experimental animals. Robust and accurate monitoring assays enable researchers to effectively detect and manage microbial diseases, safeguarding animal health and ensuring reliable research outcomes.