Abstract
Arthropods harbor a diverse array of microbes that profoundly influence many aspects of host biology, including vector competence. Additionally, symbionts can be engineered to produce molecules that inhibit pathogens. Due to their intimate association with the host, microbes have developed strategies that facilitate their transmission, either horizontally or vertically, to conspecifics. These attributes make microbes attractive agents for applied strategies to control arthropod-borne disease. Here we discuss the recent advances in microbial control approaches to reduce the burden of pathogens such as Zika, Dengue and Chikungunya viruses, and Trypanosome and Plasmodium parasites. We also highlight where further investigation is warranted.
Highlights
While conventional vector control strategies have reduced the burden of some VBD, novel strategies are required
Microbes have several desirable properties for applied control strategies, the ability to disseminate through vector populations
Coupling this with the propensity of symbiotic microbes to interfere with pathogen development in the host or by engineering microbes to modulate vector competence vectors, microbial strategies offer great promise for control of important VBDs
Summary
While conventional vector control strategies have reduced the burden of some VBD, novel strategies are required.
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