Abstract
Using whole cell Baeyer–Villiger biooxidation as a key step and depending on the choice of the biocatalyst { E. coli TOP10[pQR239] or Acinetobacter TD63}, the synthesis of nearly enantiopure N-protected (1 R,5 R)-(−)-Geisman–Waiss lactone (92% ee) or its (1 R,5 S)-(−) regioisomer (98% ee) be performed.
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