Abstract
Radionuclide generators employed for the production of short-lived radionuclides may be contaminated with microorganisms during use, although this may not result in significant microbial contamination of the eluate. The mechanism by which this reduction was achieved was examined, using technetium 99m generators deliberately contaminated with known numbers of Escherichia coli. Results indicated that a small proportion of the inoculum was eluted from loaded (‘active’) or unloaded columns suggesting that organisms were entrapped in the alumina bed. Cell death occurred and could be caused by significant exposure to radiation, and the toxicity of aluminium and molybdate ions. Loss of viability led to an increased release of pyrogenic material into the eluate.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
