Abstract
Biomolecules positioned at interfaces have spawned many applications in bioanalysis, biophysics, and cell biology. This Highlight describes recent developments in the research areas of protein and DNA arrays, and single-molecule sensing. We cover the ultrasensitive scanning of conventional microarrays as well as the generation of arrays composed of individual molecules. The combination of these tools has improved the detection limits and the dynamic range of microarray analysis, helped develop powerful single-molecule sequencing approaches, and offered biophysical examination with high throughput and molecular detail. The topic of this Highlight integrates several disciplines and is written for interested chemists, biophysicists and nanotechnologists.
Highlights
Analyzing biomolecular interactions with microarrays has helped usher in the genomic and proteomic area and revolutionized the biosciences
We cover the ultrasensitive scanning of conventional microarrays as well as the generation of arrays composed of individual molecules
This Highlight has described the exciting interface between single-molecule sensing and biomolecular arrays
Summary
Biomolecules positioned at interfaces have spawned many applications in bioanalysis, biophysics, and cell biology This Highlight describes recent developments in the research areas of protein and DNA arrays, and single-molecule sensing. We cover the ultrasensitive scanning of conventional microarrays as well as the generation of arrays composed of individual molecules The combination of these tools has improved the detection limits and the dynamic range of microarray analysis, helped develop powerful singlemolecule sequencing approaches, and offered biophysical examination with high throughput and molecular detail. The topic of this Highlight integrates several disciplines and is written for interested chemists, biophysicists and nanotechnologists
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