Microarray analysis of vascular endothelial growth factor (VEGF)-dependent angiogenic biomarkers in squamous cell carcinoma (SCCA) and adenocarcinoma (AC) of the cervix

Abstract

of HIF1α and VEGFA was present in 75% of both SCCA and AC cases. Conclusions: These data suggest that biomarkers along the VEGF-dependent pathway of tumor angiogenesis are not differentially expressed between SCCA and AC of the cervix. Ligand binding and sequestration using the monoclonal antibody, bevacizumab, is likely to inhibit angiogenesis in women suffering from advanced SCCA or AC of the cervix. The extent to which pre-treatment microarray analysis to guide therapy decisions requires further investigation.