Abstract
Aim: DNA methylation is involved in esophageal adenocarcinoma (EAC) and Barrett's esophagus (BE). Microarchitectures of on-neoplastic BE associated with DNA methylation status were examined using magnifying narrow-band imaging (NBI) endoscopy. Patients and methods: Using biopsies from non-neoplastic BE without cancer (n=66; N group), with EAC (n=27; ADJ group) and EAC tissue (n=22; T group), methylation of N33, DPYS, SLC16A12, miR124a3 andmiR34bc genes were quantified. MagnifyingNBI features of non-neoplastic BE were classified according to their morphologies. Results: TheADJ and T groups presented higher DNA methylation compared with theN group. Magnifying NBI endoscopic features of non-neoplastic BE also correlated with DNA methylation as an independent factor. Conclusion: Microarchitectures of BE visualized by magnifying NBI endoscopy correlated with DNA methylation.
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