Microaneurysm Turnover in Mild Non-Proliferative Diabetic Retinopathy is Associated with Progression and Development of Vision-Threatening Complications: A 5-Year Longitudinal Study.

Ana Rita Santos,José Cunha-Vaz,Ines P Marques,João Figueira,Luis Mendes,Maria Helena Madeira,Diana Tavares,Conceição Lobo

doi:10.3390/jcm10102142

Abstract

Background: Analysis of retinal microaneurysm turnover (MAT) has been previously shown to contribute to the identification of eyes at risk of developing clinically significant complications associated with diabetic retinopathy (DR). We propose to further characterize MAT as a predictive biomarker of DR progression and development of vision-threatening complications. Methods: 212 individuals with type 2 diabetes (T2D; ETDRS grades 20 and 35) were evaluated annually in a 5-year prospective, longitudinal study, by color fundus photography and optical coherence tomography. Endpoints were diabetic macular edema (DME) or proliferative retinopathy (PDR). MAT analysis included determination of MA formation and disappearance rates, automatically assessed using the RetMarkerDR®. Retinopathy severity progression was evaluated using step increases in ETDRS severity levels. Results: Of the 212 individuals, 172 completed the 5-year follow-up study or developed an endpoint (n = 27). MAT calculated at 1 year showed a significant difference between groups of endpoint developments (p = 0.018), particularly MA disappearance rate (p = 0.007). MAT also showed a significant difference between eyes with different ETDRS severity progression in the 5-year period (p = 0.035). Conclusions: MAT is an indicator of the development of DME and/or PDR as well as of DR severity progression in T2D individuals with mild retinopathy.

Highlights

From the 212 individuals recruited with diagnosed adult-onset type 2 diabetes (T2D) and Early Treatment Diabetic Retinopathy Study (ETDRS)
When analyzing the demographic characteristics, the duration of diabetes was significantly different between the two baseline ETDRS groups (p = 0.011)
The present study shows that microaneurysm turnover (MAT) and MA formation rates are related to the development of vision-threatening complications and worsening of diabetic retinopathy (DR) severity over a 5-year period, being significantly increased in individuals that showed severity progression when compared to those who improved or maintained their disease grade

Summary

Introduction

Diabetic retinopathy (DR) is still one of the leading causes of blindness in the world [1]. DR, such as macular edema and proliferative retinopathy, is expected to exponentially increase [2]. Stages of DR, initially characterized by the presence of microaneurysms and/or dot hemorrhages, can predict progression to vision-threatening retinopathy. These characteristics proved to be indicators of increased risk for microvascular complications [1]. The. Analysis of retinal microaneurysm turnover (MAT) has been previously shown to contribute to the identification of eyes at risk of developing clinically significant complications associated with diabetic retinopathy (DR). We propose to further characterize MAT as a predictive biomarker of DR progression and development of vision-threatening complications

Methods

Results

Discussion

Conclusion