Abstract
Years before the progression to diabetes mellitus type II patients can get by with a pre-diabetes called period. The pathogenesis involved pre-diabetes is insulin resistance Objective: This paper discusses the frequency of microalbuminuria in non-diabetic population, but with increased metabolic risk, and attempts to assess whether there is any correlation of microalbuminuria with data from glucose metabolism. A total of 132 nondiabetic patients who presented one or more risk factors for changes in glucose metabolism were included in the study: arterial hypertension; obesity; first-degree relatives with diabetes; individuals of Hispanic-American, Asian and African-American ethnicities; mothers of newborns who are large for gestational age (LGA) or who had gestational diabetes; serum measurements in fasting HDL cholesterol 250 mg/dL. The results showed a frequency of abnormal microalbuminuria for the method in 16% of this population, and the presence of lower levels of HDL-cholesterol and creatinine clearance in this population. There was a positive correlation between microalbuminury and serum creatinine and uric acid. Our study suggests that microalbuminuria be evaluated as a marker of incipient nephropathy in non-diabetic population with increased metabolic risk.
Highlights
Years before the progression to diabetes mellitus type II patients can get by with a pre-diabetes called period
The pathogenesis involved pre-diabetes is insulin resistance Objective: This paper discusses the frequency of microalbuminuria in non-diabetic population, but with increased metabolic risk, and attempts to assess whether there is any correlation of microalbuminuria with data from glucose metabolism
There was no statistically significant correlation between microalbuminuria with glucose or glucose tolerance testing (GTT) or homeostasis model assessment of insulin resistance index (HOMA-IR) or between these anthropometric data; as there was no correlation with cholesterol and triglycerides data; there was a positive correlation between microalbuminuria and serum creatinine (r = 0.6, p < 0.0001), Figure 1; and positive correlation with serum uric acid levels (r = 0.3, p < 0.001), Figure 2
Summary
Years before the progression to diabetes mellitus type II patients can get by with a pre-diabetes called period. The pathogenesis involved pre-diabetes is insulin resistance Objective: This paper discusses the frequency of microalbuminuria in non-diabetic population, but with increased metabolic risk, and attempts to assess whether there is any correlation of microalbuminuria with data from glucose metabolism. Conclusion: Our study suggests that microalbuminuria be evaluated as a marker of incipient nephropathy in non-diabetic population with increased metabolic risk. Years before the progression to type II diabetes mellitus (DM2), the patient can live in a period called pre-diabetes. Another study showed that microalbuminuria was significantly higher in individuals with pre-diabetes compared to a group with normal glucose levels.[8] The association of microalbuminuria with insulin resistance in nondiabetic patients has been demonstrated.[9,10]
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