MICROALBUMINURIA IN HYPERTENSIVE PATIENTS WITH TYPE 2 DIABETES MELLITUS: PP.17.153

Abstract

Objective: Microalbuminuria (MA) is the earliest indicator of chronic kidney disease (CKD) in patients with diabetes mellitus and hypertension. The aim of this study was to compare the values of microalbuminuria in a group of hypertensive patients with and without type 2 diabetes mellitus. Design and Methods: Our study included a group of 81 patients with arterial hypertension (mean age ± S.D: 65 ± 9 years) and a second group of 76 patients with arterial hypertension and type 2 diabetes mellitus (63 ± 9 years) hospitalized in a two years period. Their systolic blood pressure (SBP), diastolic blood pressure (DBP), serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglycerides (TG), body mass index (BMI), glycemia, serum uric acid (SUA), creatinine, blood urea nitrogen (BUN), and microalbuminuria levels were compared using the t Student's test. Results: In our study, hypertensive patients with type 2 diabetes mellitus had significant higher glycemia (295 ± 60 mg/dL vs. 88 ± 14 mg/dL, p < 0.001), microalbuminuria (103 ± 17 mg/24 hours vs. 60 ± 13 mg/24 hours, p < 0.001), TG (308 ± 96 mg/dL vs. 140 ± 35 mg/dL, p = 0.0027), compared to hypertensive patients. There were no significant differences between the values of LDL-C, creatinine and SUA, in the two groups. Conclusions: Our study showed that patients with both arterial hypertension and diabetes mellitus have increased values of microalbuminuria, which is considered to be an early stage of diabetic nephropathy. These results call for early detection and a good control of diabetes to reduce the burden of diabetic kidney disease.