Abstract
A sensitive micro-scale method based on isocratic elution reversed-phase ion-pair chromatography for the determination of bamifylline and its major metabolite (AC 119) in human plasma is described. The method is based on a liquid—liquid extraction clean-up followed by analysis on an LC-Packings Fusica (Delta Pak, RP-18, 5 μm, 300 Å) column (15 cm × 330 μm, I.D.) with 0.03 M heptanesulphonate (pH 3.5)-acetonitrile (7:3, v/v) as the mobile phase. Data with respect to recovery, reproducibility and limits of detection are reported and discussed.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
