Abstract
Abstract A custom-designed microelectromechanical force transducer, with a volume of less than 1 mm3, is being developed to quantify forces generated in isolated cardiac muscle cells. A single heart cell will be attached to flexible, hinged polysilicon plates submerged in a nutrient solution. As the cell contracts, the plates will bend, and the contractile force can be measured based on the known spring constant of the plate and the amount of deflection. Prototype structures have been fabricated and have been mechanically tested. We have demonstrated that living rat heart cells can be attached to polysilicon using a commercial silicone sealant. We have also observed that polysilicon is an inert material when exposed to cardiac cells and their saline environment, and has no detectable effect on the cells themselves.
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