Abstract
miRNAs are endogenous, small (21-22 nucleotides), single-stranded, non-coding RNAs recently discovered (1). miRNAs complexed with Ago proteins (RISC complex) regulate gene expression by binding to reverse complementary sequences in their target mRNAs leading to mRNA degradation and/or repression of protein translation (2). Circulating miRNAs can be detected in serum or plasma and have been proposed as potential biomarkers for cardiovascular diseases, with high sensitivity (3).
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