Micro-RNA Mediated Signalling Circuits in Endocrine-Dependent Malignancies of Human Reproductive System

Abstract

Breast, ovarian, endometrial, prostate and cervical cancers are considered as the major endocrine-dependent malignancies associated with human reproductive system. Current tools used for diagnosis and therapeutics of these malignancies mainly exploit the hormone-sensitivity associated with them. Nonetheless, they often fail to give appreciable outcomes in terms of prognosis and survival rates. miRNAs have emerged as one of the key players dictating the pathophysiology of endocrine-dependent malignancies and present themselves as apt candidates to be developed as potential biomarkers or therapeutic targets for the early prognosis as well as treatment of these diseases. In this review, we have high-lighted the regulatory networks controlled by the promising candidate miRNAs in the pathophysiology of the major endocrinedependent reproductive system-associated malignancies.