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Abstract
Constructing the interconnected porous biomaterials scaffolds with osteogenesis and angiogenesis capacity is extremely important for efficient bone tissue engineering. Herein, we fabricated a bioactive micro-nano composite scaffolds with excellent in vitro osteogenesis and angiogenesis capacity, based on poly (lactic-co-glycolic acid) (PLGA) incorporated with micro-nano bioactive glass (MNBG). The results showed that the addition of MNBG enlarged the pore size, increased the compressive modulus (4 times improvement), enhanced the physiological stability and apatite-forming ability of porous PLGA scaffolds. The in vitro studies indicated that the PLGA-MNBG porous scaffold could enhance the mouse bone mesenchymal stem cells (mBMSCs) attachment, proliferation, and promote the expression of osteogenesis marker (ALP). Additionally, PLGA-MNBG could also support the attachment and proliferation of human umbilical vein endothelial cells (HUVECs), and significantly enhanced the expression of angiogenesis marker (CD31) of HUVECs. The as-prepared bioactive PLGA-MNBG nanocomposites scaffolds with good osteogenesis and angiogenesis probably have a promising application for bone tissue regeneration.
Highlights
Bone defects, caused by breaks, tumors, and traumas, bring great pressure to public health, and become an urgent problem to be resolved (Li et al, 2018a; Zheng et al, 2018)
The XRD analysis showed a diffuse peak at ā¼23ā¦ (2Īø), which was the characteristic of glassy state, indicating the representative amorphous structure of micro-nano bioactive glass (MNBG) (Figure 1C) which could contribute to the ion release (Figure S2)
Whereas, when the MNBG incorporation was up to 40% w/w, the effect of PLGA wrapping on MNBG makes the wall of the scaffold thickened, resulting in the reduction of the pore diameter of the scaffold
Summary
Bone defects, caused by breaks, tumors, and traumas, bring great pressure to public health, and become an urgent problem to be resolved (Li et al, 2018a; Zheng et al, 2018). Bone scaffolds should have the ability to mobilize cells to reach the lesion place after implanted, until the regenerated tissue is enough stabilized to support the native bone. The scaffolds need to serve as extracellular matrices (ECMs) temporarily to provided structural support and facilitate cells survival, attachment, proliferation, and differentiation, with the final objectives of generating functional bone tissue. Based on the bionics principle and the previous reports about complex architecture of bone tissue, three-dimensional (3D) scaffolds with porous structure and functional inorganic particle are considered to be one of a promising means to resolve above problems and achieve the purpose of bone tissue repair (Lei et al, 2012; Chen and Liu, 2016; Chen et al, 2016)
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