Abstract
The antitoxin titres obtained by the micro cell culture colour change method was compared with those determined by the rabbit skin test. The results confirmed a high correlation between the two techniques. The cell culture method was successfully applied to determine the relative potency of diphtheria toxoid preparations. Sero-epidemiological patterns of the age distribution of diphtheria antitoxin which were explored by this method on 243 sera from healthy Japanese agreed with that obtained by the Schick test. It is concluded that the micro cell culture colour change method using VERO cells is a highly recommended procedure for diphtheria toxin and antitoxin determinations because of its sensitivity, reproducibility and economy of time, labour and materials.
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