Abstract
Michel Caboche, an outstanding plant molecular and cell biologist.
Highlights
Michel Caboche was born on April 25, 1946 in Rotangy, a small village in Picardy, in a farming family
He decided to study the nitrate assimilation pathway, and more generally the assimilation of nitrogen, an essential function in the plant kingdom. As throughout his career, he will lead many researchers, PhD students, post-docs or more confirmed scientists, who will follow in his wake. He undertook this study using a genetic approach by isolating mutants unable of using nitrate because they were deficient in nitrate reductase (NR)
This selection is based on resistance to chlorate, a classic weed killer used by gardeners, which NR reduces to chlorite, a compound that is toxic to plant cells [7]. This approach proved to be extremely fruitful, as it allowed the isolation of numerous mutants divided into 7 complementation groups corresponding to the nitrate reductase structural gene locus and to 6 loci corresponding to the biosynthesis of its cofactor which contains a molybdenum atom [8, 9]
Summary
Michel Caboche was born on April 25, 1946 in Rotangy, a small village in Picardy, in a farming family.
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