Abstract

Michael Cyclization of Polarized Systems: Synthesis and in vitro Anti-Diabetic Evaluation of Some Novel Pyrimidine, Pyridine, Pyrazole and Pyrazolo[3,4-b ]pyridine Derivatives

Highlights

  • N ITROGEN-containing heterocyclic molecules constitute the largest portion of chemical entities, which are part of many natural products, fine chemicals, and biologically active pharmaceuticals, which are vital for enhancing quality of life.[1,2,3,4,5,6,7,8,9,10,11] In this respect and various approaches for the preparation of these privileged structures with drug-like properties have been developed on various synthetic strategies

  • Many studies have been shown that compounds containing the pyrimidine ring possess antidiabetic, antibacterial, antifungal, antimalarial, and anticonvulsant activities,[12,13,14,15,16] and anticancer activities,[17,18] and many of pyrimidine compounds were reported to act as calcium channel blockers,[19] and as potential central nervous system (CNS) depressants.[20,21]

  • Based on the above considerations and in continuation of our research on biologically potent heterocyclic derivatives,[32,33,34,35,36,37,38] we report the synthesis, structural elucidation and antidiabetic activity of some new azoles and azines prepared from commercially available reagents

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Summary

Introduction

N ITROGEN-containing heterocyclic molecules constitute the largest portion of chemical entities, which are part of many natural products, fine chemicals, and biologically active pharmaceuticals, which are vital for enhancing quality of life.[1,2,3,4,5,6,7,8,9,10,11] In this respect and various approaches for the preparation of these privileged structures with drug-like properties have been developed on various synthetic strategies. Based on the above considerations and in continuation of our research on biologically potent heterocyclic derivatives,[32,33,34,35,36,37,38] we report the synthesis, structural elucidation and antidiabetic activity of some new azoles and azines prepared from commercially available reagents

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