Abstract
Pansare and co-workers report an enantioselective route toward the aryloctahydroindole core of several natural products. Their approach is based on the highly enantio- and diastereoselective Michael addition between ketones 1 and nitroalkenes 2 using the triamine salt catalyst 3. The resulting γ-nitro ketone 4a was diastereoselectively transformed into the cis-octahydro-indole 7 in five steps. This intermediate was further functionalized to tetracycle 8, thus completing a formal synthesis of (-)-pancracine.
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