Abstract
Abstract By means of surface tension measurement (ring detachment method) mixed micellization and mixed adsorbed film formation were studied between an amphiphilic drug (amitriptyline hydrochloride – AMT) and nonionic surfactants (Tritons and Tweens) at different mole fractions. From the equilibrium surface tension measurements critical micelle concentration (CMC), maximum surface excess (Γmax) and minimum area per surfactant molecule at the air/solution interface (Amin) were obtained. The theories of Rosen, Rubingh and Maeda were applied to analyse the results. Different thermodynamic parameters, viz. free energy of micellization (ΔGo m), standard Gibbs energy of adsorption (ΔGo ads), and minimum energy of surface (Gmin) were evaluated. In the mixed micelles, presence of nonionic surfactants between the head groups of drug molecules decreases the repulsion among head groups. As a result, the CMC and Amin decrease while Γmax increases. Interaction parameters of micelles (βm) and monolayer (βs) indicate that the drug surfactant systems show better interaction at the interface than in micelles.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
