Abstract
Micellization of asymmetric triblock copolymers (TBCs) contained chemically complementary poly(ethylene oxide) (Mn=6, 14 and 35kDa) and polyacrylamide of different chain length (PAAm-b-PEO-b-PAAm) was studied using visible spectroscopy, static light scattering, photography and transmission electron microscopy. The formation of “hairy-type” and “flower-like” micelles consequently in aqueous and aqueous/ethanol (30/70v/v) solutions was established. An unusual morphology of the “hairy-type” micelles was found in aqueous solutions of TBC, which comprised the lengthiest PEO and PAAm blocks. Significant encapsulation of a model crystalline drug prednisolon (PS) by the “hairy” micelles due to hydrogen bonds and hydrophobic interactions was determined by ultraviolet–visible spectroscopy and Fourier transform infrared spectroscopy. This resulted in the appearance of “snow-flakes-like” micellar structures. The possibility of regulating crystalline properties of the drug in micellar nanocontainers was shown with differential scanning calorimetry and wide-angle X-ray scattering.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
