Abstract
Capillary electromigration techniques have proven their capabilities in detection of variety of analytes from inorganic ions and small organic molecules through bio(macro)molecules to large analytes such as cells or nano/micro particles. Also broad range of potential applications includes food and environmental analysis, biomedical and pharmaceutical investigations or even diagnostics.In this work, it was demonstrated that capillary micellar electrokinetic chromatography is an excellent tool extremely helpful in investigations focused on prebiotic synthesis of molecules essential for formation of life on early Earth – nucleobases. In particular, rapid separation of nucleobases (< 2 min) was achieved in 40 mM borate buffer separation electrolyte containing 60 mM sodium dodecyl sulfate as an additive. This approach enabled detection of nucleobases formed in thermolysed formamide under conditions simulating the environment occurring on early Earth. Moreover, polydopamine-based molecularly imprinted polymers specific to thymine and uracil improved detection of these low abundant products.
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