Abstract
This paper describes the development of an electrophoretic method used to analyse seven water-soluble vitamins, and its use in the analysis of pharmaceutical formulations. Thiamine, nicotinamide, nicotinic acid, pyridoxine, ascorbic acid, folic acid and riboflavin were separated from one another in 7min by micellar electrokinetic capillary chromatography using a carrier containing sodium dodecyl sulphate as surfactant, and were subsequently detected spectrophotometrically using a diode-array detector. The limits of detection (S/N=3) ranged between 0.08μgml–1 for folic acid and 0.25μgml–1 for nicotinamide and thiamine. The relative standard deviation of the proposed method was less than 6% for all formulation samples.
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