Abstract
The kinetics of oxidation of the Norfloxacin (NOR) by sodium salt of p-toluene sulphonamide (chloramine-T) has been studied in presence of an anionic surfactant, that is, sodium dodecylsulphate (SDS) in perchloric acid medium at 308 K. The reactions show first order, fractional order and inverse fractional order dependence of rate with respect to NOR, chloramines-T and perchloric acid, respectively. Dilute micelle-forming anionic surfactant slightly speed the reaction but the reaction rate decreases sharply with increasing surfactant concentration. The kinetic data have been rationalized in terms of various micelle kinetic models and binding parameters have been evaluated. The addition of reduced product of the oxidant (phthalimide) has decreased the rate of reaction. The rate of reaction also decreased with increase in salt concentrations. Effect of ionic strength and solvent polarity of the medium on the rate of reaction were studied. The oxidation products were identified by GC-MS analysis. Investigations of the reaction at different temperatures allowed the determination of the activation parameters with respect to the slow step of proposed mechanism.
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