Micellar assembly leading to structural growth/transition in normal and reverse Tetronics® in single and mixed solution environment.

Abstract

This study scrutinizes the self-association of ethylene oxide (EO)-propylene oxide (PO)-based star-shaped block copolymers as normal Tetronic® (T904) and reverse Tetronic® R (T90R4) with varying molecular characteristics and different hydrophilic-hydrophobic ratios in an aqueous solution environment. These thermo-responsive solutions appear clear, transparent or bluish up to 10%w/v, which anticipated the probable transition of unimers to spherical or ellipsoidal micelles which is complemented by scattering experiments. In a single-solution environment, 10%w/v T904 formed star-shaped micelles at ambient temperature and exhibited a micellar growth/transition with temperature ageing. While 10%w/v T90R4 exists as unimers or a Gaussian coil over a wide range of temperature. Very interestingly, close to the cloud point (CP) flower-shaped spherical and ellipsoidal micelles were formed. A similar proposed micellar scheme was also examined for mixed systems T904 : T90R4 in varying ratios (1 : 0, 3 : 1, 1 : 1, 1 : 3 and 0 : 1) giving an account to the solution behavior of the mixtures. An amalgamation of dynamic light scattering (DLS) and small-angle neutron scattering (SANS) techniques achieved the thorough extraction of the structural parameters of the micellar system. The hydrodynamic diameter (Dh) of the micelles with temperature variation was evaluated from dynamic light scattering (DLS) while the structure factor of the micelles was found by employing small-angle neutron scattering (SANS). Furthermore, the single and mixed micellar systems were quantitatively and qualitatively examined for anticancer drug solubilization using UV-vis spectroscopy for their superior use as potential nanocargos.