Abstract
Abstract The construction and performance characteristics of ion-selective electrode for mianserin-drug cation, based on ion-pair complex with dinonylnaphthalenesulfphonate anion in a PVC matrix are described. The electrode shows a near-Nersntian response in the range 10−2 - 5 × 10−6 M drug concentration. Its selectivity relative to various cations is reported. The potentiometric methods are used to determine mianserin hydrochloride with good results. The electrode is also useful to the determination of content uniformity and dissolution-rate of uncoated mianserin tablets. The physical processes are numerically simulated by typical equations.
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