Mg ions incorporated phytic acid (PA) and zoledronic acid (ZA) of metal-organic complex coating on biodegradable magnesium for orthopedic implants application

Abstract

In this study, Mg ions incorporated phytic acid (PA) and zoledronic acid (ZA) of metal-organic complex coating was built on Mg substrate. This coating aims to fulfill the corrosion controlling and differential regulation on osteoblast vs. osteoclast responses simultaneously. PA and ZA molecules were co-immobilized on the alkaline pretreated Mg by a facile one-step dip-coating method. Such immobilization process was executed by the chelation reaction between PA/ZA molecules and in-situ released Mg ions. This coating showed a homogeneous structure with metal-organic like framework. The electrochemical corrosion resistance and long-term degradation behavior of coated samples were remarkably improved. Consequently, the well-controlled Mg ion release, as well as the osteo-compatible PA molecule, promoted the proliferation of pre-osteoblast cells (MC3T3-E1). Moreover, this coating significantly suppressed both the proliferation and differentiation of osteoclast cells owing to the nature of ZA. This metal-organic complex coating offers a promising modifying strategy for Mg-based orthopedic implants for osteoporotic fracture healing.