Abstract
AbstractMexiletine is an antiarrhythmic drug that has a Na+ channel blocking activity. The aim of the present study was to evaluate whether mexiletine had a local anesthetic effect as assessed by sciatic nerve blockade. Thus, the potency and duration of action of mexiletine on sciatic nerve blockade in terms of motor function and nociception were evaluated. Two local anesthetics, bupivacaine and lidocaine, were used as controls. Mexiletine produced a dose‐related local anesthetic effect on sciatic nerve blockade. The rank potency was bupivacaine >lidocaine >mexiletine (P<0.05 for each comparison). On an equi‐potent basis, the rank duration of action was bupivacaine>mexiletine>lidocaine (P<0.05 for each comparison). Co‐administration of mexiletine with bupivacaine produced an additive effect on sciatic nerve blockade. In conclusion, mexiletine had a local anesthetic effect on sciatic nerve blockades of motor function and nociception. Co‐administration of mexiletine with bupivacaine produced an additive effect on sciatic nerve blockade. Drug Dev. Res. 67:905–909, 2006. © 2007 Wiley‐Liss, Inc.
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