Abstract
Structural-functional state of kidneys under conditions of aseptic fever development, induced by pyrogenal (25 mg/kg) injection, was studied in the experiment on 36 white non-linear male rats weighting 0.16-0.2 kg, maintained on hypo-sodium diet. The identified changes included reduction of glomerular filtration rate and proximal sodium reabsorption, increase of protein excretion, vacuolar epithelial dystrophy of the proximal tubules, and focal character of changes in protein properties with the shift of colouring to red colour during the first fever stage. Determined modifications reflect the intensification of the compensatory reactions, directed on the providing of body temperature rise during the first fever stage through increasing of heat production and limitation of heat loss. A significant protective effect of mexidol on the structural-functional state of kidneys during the progression of first fever stage is demonstrated.
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