METTL3-Mediated m6A Modification Links Liver Homeostasis and Pathology

Abstract

RNA modification is a new paradigm of epigenetic regulation of gene expression. This evolving field has been coined as RNA epigenetics or epitranscriptomics. Extensive studies over recent years have shown that RNA modifications affect multiple steps of RNA metabolism, including RNA export, splicing, processing, stability, degradation, and translation. Among different forms of RNA modifications, N6-methyladenosine (m6A) modification is the most prevalent form of messenger RNA modification in eukaryotes, which is critically implicated in the regulation of cellular functions.